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Maraviroc Mechanism of Action (MOA)

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Maraviroc Mechanism of Action (MOA)

Maraviroc is a potential antiviral drugs for the HIV-1 (R5 strain). Let’s review it’s mechanism of action. (See the side effects in the video and the description below. Also, review the references.)

About serious side effects of Maraviroc (Reference: https://clinicalinfo.hiv.gov/en/drugs/maraviroc/patient)
Note: Maraviroc can cause serious, life-threatening side effects. These include liver problems and severe skin rash and allergic reactions.

References:
Maraviroc
https://en.wikipedia.org/wiki/Maraviroc
Book: Goodman and Gilman
Maraviroc blocks the binding of the HIV outer envelope protein gp120 to the CCR5 chemokine receptor
Brunton, Laurence; Knollman, Bjorn; Hilal-Dandan, Randa. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (Goodman and Gilman"S the Pharmacological Basis of Therapeutics) . McGraw-Hill Education. Kindle Edition. 
Location 54074

CCR5
https://en.wikipedia.org/wiki/CCR5
On monocytes
https://journals.lww.com/shockjournal/Fulltext/2019/11000/CCR5_Positive_Inflammatory_Monocytes_are_Crucial.16.aspx
CCR5 and Cytotoxic T cells
https://pubmed.ncbi.nlm.nih.gov/31034775/
CCR5 Receptor Antagonists
https://en.wikipedia.org/wiki/CCR5_receptor_antagonist#Drug_development
HIV.Gov
https://clinicalinfo.hiv.gov/en/drugs/maraviroc/patient
G-protein coupled receptors
https://en.wikipedia.org/wiki/G_protein-coupled_receptor
CCL5
https://en.wikipedia.org/wiki/CCL5

In this lecture Dr. Mobeen will discuss:

1. Overview of the lecture. (1:19)

2. Introduction to maraviroc. (4:09)

3. Mechanism of the drug. (5:24)

4. Role of CCR5 in the mechanism of maraviroc. (13:57)

5. Regulated on activation normal T cell expressed and secreted. (RANTES/CCL5) (18:20)

6. Brief summary of HIV virus. (20:36)  

7. Action of maraviroc against HIV. (26:36)

8. Side effects of maraviroc. (29:57)

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

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